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Oxford, AstraZeneca Vaccine Gets U.K. Nod. How Is It Different From Other Shots?


The U.K. authorized a #Covid-19 vaccine developed by #AstraZeneca PLC and the #University of #Oxford, the second shot to get the green light in the country and the third to be cleared for emergency use in the #West. The authorization follows a similar one in the U.K. earlier this month for a vaccine made by #Pfizer #Inc. and #BioNTech SE. The #Pfizer shot and one by #Moderna #Inc. have both been authorized in the U.S.

The U.K. authorization of #AstraZeneca’s shot comes as #Britain finds itself at the center of concerns over this winter’s fast-spreading coronavirus cases, both in #Europe and the U.S. The U.K. earlier this month said it had identified a new variant of the virus that appeared more contagious than previously known variants. U.K. officials have said a fast vaccine rollout could help curb the spread of this new virus form.

#What does the authorization mean?

#AstraZeneca and #Oxford can now distribute their two-shot vaccine across the U.K. The two #British organizations have long made plans for manufacturing and distribution in the U.K., and that should add significantly to existing vaccine supplies from #Pfizer and #BioNTech.

#Is this vaccine effective against the new variant identified in the U.K.?
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#British officials say the new mutations appear to make the virus more contagious. #But they say the variant should be just as vulnerable to the several vaccines that have been deployed against the coronavirus, including #AstraZeneca’s.

#When will it be available in the U.S.?

#Not immediately. The #Food and #Drug #Administration is waiting to see data from human trials now being conducted in the U.S. before reviewing the vaccine for use. #AstraZeneca has still been recruiting trial participants but, given rising infections, could have the necessary data for the FDA by #February.

#How many doses can #AstraZeneca roll out?

The company previously said it had around four million doses ready for distribution in the U.K. and plans to ramp up deliveries from that. A person familiar with the plans said company executives expect that by late #January, the company can provide around four million doses a week. The U.K. has preordered up to 100 million doses.

#What’s the difference between the #AstraZeneca-Oxford shot and the #Pfizer vaccine?

#Both require two doses. #AstraZeneca’s vaccine is more similar to traditional vaccine technology, with a twist: introducing a weakened strain of a virus, in this case from a chimpanzee, into the body. The virus carries genetic code specific to the coronavirus to trigger an immune response. The vaccines made by #Pfizer-BioNTech and #Moderna, both of which are deployed in the U.S., use a newer technology called messenger RNA to trigger an immune response.

#Is #AstraZeneca’s shot proven to be safe and effective?

#Human trials show the shot is safe and that it was about 62% effective for the majority of trial participants who were given it. #That compares with 95% for #Pfizer and 94% for #Moderna. A small subset of #Oxford trial volunteers aged 55 and younger were given a half dose followed by a full dose. The half-dose regimen showed the vaccine to be 90% effective, though scientists said they couldn’t fully explain the better result and want to study it more.

The U.K. became the first #Western nation to vaccinate patients against #Covid-19. WSJ explains how the country is planning to roll out the #BioNTech-Pfizer vaccine at record speed, making it a test case for the rest of the world. #Photo: #Jacob #King/Bloomberg #News (#Originally published #Dec. 8, 2020)

#Write to #Jenny #Strasburg at [email protected]

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#Copyright ©2020 #Dow #Jones & #Company, #Inc. #All #Rights #Reserved. 87990cbe856818d5eddac44c7b1cdeb8



[ source link ]
https://www.wsj.com/articles/oxford-astrazeneca-vaccine-gets-u-k-nod-how-is-it-different-than-other-shots-11609317308

##Oxford ##AstraZeneca ##Vaccine ##Nod ##Shots

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