#Damage and inflammation in blood vessels could be a consequence of the body’s inflammatory response to COVID-19
A study of how it affects COVID-19 the brain detected damage and inflammation in the blood vessels, which could be a consequence of the body’s inflammatory response to the virus, since in the tissues analyzed, no traces of infection were found.
#Researchers from #National #Institutes of #Health (NIH) in the #United #States analyzed brain tissue from 19 deaths from the disease, in which there were “systematically, marks of damage” caused by thinning and leaking blood vessels.
#However, they did not see “signs of SARS-CoV-2 in tissue samples, suggesting that the damage was not caused by a direct viral attack on the brain, “according to the results published in the #New #England #Journal of #Medicine.
The brains of patients who contract the COVID-19 “They may be susceptible to microvascular blood vessel damage” and the results “suggest that they may be caused by the body’s inflammatory response to the virus,” according to the study’s lead author #Avindra #Nath of the NIH.
The expert hopes that these results “will help doctors understand the full spectrum of problems that patients may suffer in order to propose better treatments ”.
#Although COVID-19 is primarily a respiratory disease, patients often experience neurological problems such as headaches, delirium, cognitive dysfunction, dizziness, fatigue, or loss of the sense of smell, and may occasionally suffer from strokes and other neuropathologies.
The team examined in depth brain tissue samples from 19 patients who died from #March to #June, aged between five and 73 years and who died from a few hours to two months after showing symptoms; many had one or more risk factors, such as diabetes, obesity, and cardiovascular disease.
#Samples of the olfactory bulbs and brainstem, which are considered the brain regions most susceptible to being affected by the disease, were examined with highly sensitive magnetic resonance imaging.
The explorations revealed that both regions were “abundant” bright spots (hyperintensities), which often indicate inflammation, and other dark (hypointensities) that represent bleeding.
#In microscope analysis they saw that bright spots They contained thinner than normal blood vessels that sometimes leaked proteins from the blood into the brain, which “seemed to trigger an immune reaction.”
The spots were surrounded by blood T cells and the brain’s own immune cells, the report adds.
#In contrast, the dark spots contained clotted and leaky blood vessels, but no immune response.
The principal investigator highlighted the surprise of the team as they expected to see damage caused by the lack of oxygen and, however, they found “multifocal areas of damage which are normally associated with strokes and neuroinflammatory diseases, ”said #Nath.
#Researchers saw no signs of infection in the brain tissue samples, although they used various methods to detect the genetic material or proteins of the SARS-CoV-2.
“#Until now, our results suggest that the damage we saw may not have been caused by the SARS-CoV-2 virus that directly infects the brain, “he added.
#In the future, the team plans to study how COVID-19 damages blood vessels of the brain and if that produces some of the short-term and long-term symptoms seen in patients.
#With information from EFE
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##Patients #suffer #damage #brain #vessels #response #COVID19