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Coronavirus leaves brain damage due to inflammatory response: study

#He covid-19 #It can generate damage and inflammation in the blood vessels of the brain as a consequence of inflammatory answer of the body before the virus, since in the tissues analyzed no traces of infection were foundrevealed a study.

#Researchers from #National #Institutes of #Health (NIH) of U.S they analyzed brain tissue from 19 deceased for disease, in which there were “consistently, marks of damage” caused by thinning and leaking blood vessels.

#However, they did not see “SARS-CoV-2 signs in tissue samples, suggesting that the damage was not caused by a direct viral attack to the brain, “according to the results published #New #England #Journal of #Medicine.

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The brains of patients who contract covid-19 “may be susceptible to damage to microvascular blood vessels“and the results” suggest they may be caused by the body’s inflammatory response to the virus, “according to the study’s lead author, #Avindra #Nathfrom the NIH.

The expert hopes that these results “help physicians understand all the spectrum of problems that patients may suffer to be able to propose best treatments“.

#Although the new coronavirus is mainly a respiratory disease, patients often experience neurological problems as #Headaches, delirium, cognitive dysfunction, dizziness, fatigue O loss of sense of smell and sometimes they may suffer strokes and others neuropatologías.

The team examined brain tissue samples in depth from 19 deceased patients from #March to #June, with an age between five and 73 years and that they died from a few hours to two months after showing symptoms; many had one or more risk factors, such as diabetes, obesity and cardiovascular ailments.

#Samples of the olfactory bulbs and the brainstem, which are considered the brain regions most susceptible to being affected by the disease, were examined with MRIs very high sensitivity.

The explorations revealed that in both regions “abounded” bright spots (hyperintensities), which often indicate inflammation, and other dark (hypointensities) they represent bleeding.

#In microscope analysis they saw that the bright spots contained thinner blood vessels than normal that proteins sometimes leaked from the blood into the brain, which “seemed to trigger an immune reaction.”

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The spots were surrounded by blood T cells and their own brain immune cells, adds the report.

#In contrast, the dark spots contained clotted and leaky blood vessels, but no immune response.

The principal investigator highlighted the surprise of the team as they expected to see damage caused by the lack of oxygen and yet they found “multifocal areas of damage that are typically associated with strokes and neuroinflammatory diseases,” #Nath said.

The researchers saw no signs of infection in the brain tissue samples, although they used various methods to detect genetic material or proteins from the brain. SARS-CoV-2.

“#So far, our results suggest that the damage we saw may not have been caused by the virus of the SARS-CoV-2 that directly infects the brain, “he added

#In the future, the team plans to study how the covid-19 damages the blood vessels of the brain and if that produces some of the symptoms short and long term seen in patients.


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