Until the 77th minute, it was instead Milan (14th) who led to the points, with several opportunities from Piatek, Suso or Calhanoglu, all defeated by Szczesny, in a great evening.
Juventus side, the most dangerous had been until then Matuidi, author of two dangerous strikes.
Ronaldo had already come out in the 55th minute. Obviously diminished physically, the fivefold Golden Ball has done nothing good.
The bianconeri were therefore stuck, but they have a talent pool that makes the difference. Douglas Costa and Dybala came in and they changed everything.
For ten seconds, no more, Juve played at 100 per hour: Douglas Costa eliminated and found Dybala; a relay from Bentancur, another from Higuain and here again Dybala left Romagnoli on the spot a hook before beating Donnarumma (1-0, 77th).
With this success, Juventus takes control of the championship at the expense of Inter Milan, victorious Saturday of Hellas Verona (2-1).
Behind the two untouchable leaders, there are two more unexpected pursuers, Lazio and Cagliari.
In full confidence now and carried by a huge Nainggolan, Cagliari has indeed corrected the Fiorentina 5-2 to climb to 4th place, tied with Lazio (3rd), which on its side has hardly beaten the promoted Lecce 4-2, thanks in particular to a double of Argentinean Correa.
Cagliari remains on three consecutive victories and has been on an infernal pace for two months. The Sardinian team had lost the first two games of the season, but since then they have played ten matches without defeat, including seven successes.
The Sardinians can continue to dream of Europe, especially as their success on Sunday allows them to overtake Atalanta Bergamo (5th), held in check on the field of Sampdoria Genoa (0-0), and the AS Rome (6th), beaten 2-0 at Parma.
Faced with Fiorentina, struggling in the absence of Ribery, the big man of the match was Nainggolan.
Returned to Sardinia after a difficult season at Inter Milan, the Belgian handed out three assists and scored a goal with a fantastic strike.
Cagliari led 5-0 and was just relaxed late in the game, allowing Fiorentina (9th) to limit the damage.
In Rome, Lazio settled on the podium taking the best of Lecce. Led 2-1, the promoted even equalized when Lapadula took the penalty for Babacar pushed back by Strakosha.
But the goal was canceled after the intervention of the video assistant, who ruled that Lapadula had entered the surface at the time of the striking of Babacar.
Less than five minutes later, Lazio obtained a penalty kick, converted by Immobile. The match had rocked.
The other team of the capital, Roma, dropped to Parma after a very good run. The Giallorossi remained in effect on three victories in a row in the league and had not lost since the fifth day.
But the repetition of the matches begins to weigh for a staff overwhelmed by injuries since the beginning of the season and which is running parallel to the Europa League.
The players of Paulo Fonseca appeared so tired, especially the center-forward Dzeko, against a team of Parma on the contrary very strong.
Kolarov however hit a nice free kick on the post and Parmesan goaltender Sepe released several attempts from Pastore, Under or Zaniolo.
But it was the Parma players who managed to score, first by Sprocati (68th) and then at the end of the match by Cornelius (90 + 3), when Roma tried to equalize.