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Home World Differences in Antibody Response Affect the Severity of Covid-19 Patients

Differences in Antibody Response Affect the Severity of Covid-19 Patients – Doctors cannot predict with certainty how people are diagnosed with Covid-19, whether they will recover quickly or experience fatal complications.

The effects of Covid-19, which sometimes differ between children and adults, likely stem from differences in immune response.

Based on the blog page of the director of the United States National Institutes of Health Francis S Collins, the idea came from a new study published in the journal Nature Medicine.

The study compared the immune response between children and adults with Covid-19.

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The results showed that the antibody responses in children and people with mild Covid-19 disease were very similar. However, the cause of this complication of respiratory disease is thought to be driven by two types of antibodies that differ in various aspects of the immune response.

Illustration of a patient using a breathing apparatus.  (Shutterstock)
Illustration of a patient using a breathing apparatus. (Shutterstock)

The inventors of this theory are pediatric pulmonary scientist Lael Yonker, Center for Cystic Fibrosis of Massachusetts General Hospital (MGH), Boston, and Galit Alter immunologist, Ragon Institute of MGH,

They compared the antibody profiles of four different groups and saw that adults and children with mild Covid-19 showed no significant difference in their antibody profiles.

The differences were only seen when researchers compared the antibodies of children who had complications of multisystem inflammatory syndrome (MIS) with adults who had severe Covid-19.

In children with MIS, researchers found high levels of immunoglobulin G (IgG) antibodies, antibodies that usually help control acute infections.

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These antibodies can activate scavenger immune cells, called macrophages, to promote inflammation and more severe disease.



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